Reduce the 2.4GHz interference. Get a good router and connect when possible with ethernet cable/5GHz wifi.
If your trainer only works with bluetooth then try using a modern (bt4.0+) blutooth dongle on a usb extension cord so you can place it close to the trainer or where your devices with issues are.
Use ant+ where possible because that protocol doesn't require as much overhead as it's not lossless. I'm bad at the terminology but you get the picture. Ant broadcasts even if nothing is listening.
Stay off 2.4GHz wifi + bluetooth as much as possible. That applies to anything in the room or the next room.
/a
Any Zwift Tech Ninjas out there: Losing signal so many times Im gonna go postal
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had exactly the same issue (with BLE sensors)
every 20 minutes zwift loses PM
so, turn off wifi do not help at all
then I changed wifi channel to 1, and it almost works, I finished one workout, but the second one was more than 1 hour long, and zwift lost PM again
after all I replaced battery in PM and seems now it works without issues
so if zwift loses random sensors, then channel 1 for wifi might help
if it is always the same sensor, then replace battery
every 20 minutes zwift loses PM
so, turn off wifi do not help at all
then I changed wifi channel to 1, and it almost works, I finished one workout, but the second one was more than 1 hour long, and zwift lost PM again
after all I replaced battery in PM and seems now it works without issues
so if zwift loses random sensors, then channel 1 for wifi might help
if it is always the same sensor, then replace battery