by wintershade on Tue Jul 16, 2019 11:41 pm
As other have said, it will depend on the type of riding you're doing, how much you weigh, bike handling skills, wind conditions, rim profile/shape. There is no one size fits all answer. I have 7 sets of wheels for this reason (and partially because I'm trying to decide what I like).
If I could only have one wheelset, it would probably be my WTO 45 or Zipp 303 NSW. 45mm is kind of the perfect all-around depth that can also handle extremely windy days and doesn't make my asshole pucker frequently on decents.
If you don't experience much windy riding, then ENVE 5.6 is where I'd go next. I just got a set and love them. I found the 5 front significantly easier to manage than my Zipp 404 NSWs, which I hated, and sold. The 5 front is a very manageable wheel. I use it on my TT rig with an ENVE Disc. It's an incredible setup.
I have 808 NSWs and almost never ride them. I'm going to sell them whenever I get around to taking some photos. The front wheel really does get pushed around a lot, and you really feel the added weight accelerating.
My Bora 35 tubulars are probably my favorite wheels. They just are so slight and accelerate so well, and crosswinds are NEVER and issue. I also have Bora 50 clinchers, which really are much more noticable in the wind. But I prefer the WTO 45s and 5.6 to the Bora 50s. So I'm selling those to a buddy of mine soon.
So bottom line is, I'd probably go for something in the 45 to 60mm depth. I'm a lightweight so-so bike handler, so I'd lean do the 45 end of the spectrum and go WTO 45 or Zipp 303. If you're a bigger guy and more confident and don't live somewhere as windy as San Francisco, maybe go for 50-60mm. I'd lean to ENVE 5.6 or maybe Bora WTO 60.