Not forgetting the OP's intended use, my 2 cents is that I am running 50's on my two road bikes for training/group rides/racing. It's moderate rolling terrain with some flats around here. I was once tempted to try 80mm deep rims on the road (offered a great price). So while debating I checked out Zipps chart (not for current rim models but still a good side by side of similar designed wheels) showing time savings when going up from shallower to deeper, including combo's of say a 404 front with 808 rear. http://www.spinlitecycling.com/ZippAeroEdgeFlyer.pdf
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The time gain (watts reduced) running the next size deeper rear was very, very small.....yet you gain well over 100 grams in weight at the rear rim. Run the next size deeper both front and rear (say 808s vs 404s) the weight gain is like a half a pound all at the rims. I then checked out pics of what the pro's were riding last and this year at the major stage races.....very rarely is it greater than 50's. And when I did see an occasional sprinter bike with a larger than 50's wheel it was the rear only.....and then after losing the sprint that day, then next day in similar terrain that rider was back to 50's front and back again.....
My take away, if you do steady rides in good light wind (TT/solo or small group friendlies) then go for it as a special once in a while wheelset. If you have rides with accelerations, wind variables, want to use most days, etc I'd stick with 50's for day in and out use in all sorts of conditions.