I have now put quite a few miles on this bike with the different wheel / tire combinations, so I wanted to expand my thoughts a bit and provide a more detailed ride report:
Fit: This frame was built using dimensions from my latest fit (which I felt very comfortable with), and so that I could run a -6 degree, 120mm stem with minimal to no spacers (yet still achieve a good stack height, hence the relatively tall head tube). On paper, all the critical measurements are within a couple millimeters of each other. However, for some reason I have been having minor discomfort on the bike, mainly pressure on my hands. Part of me thinks this may be due to me not being able to ride as much as I used to (I pretty much only ride on the weekends right now due to work schedule, and unfortunately due to lack of motivation). Hopefully, I will snap out of this and start riding more, and I am hoping my body will once again appreciate the old position which it once was so used to. Also, the classic bend 3T Rotundo handlebar is not working for me, so I am going back to the shallow drop Easton EC90 SLX3.
Frame: One quality that is immediately noticeable about this frame is the stiffness in the BB area. When placed in my fluid trainer, the lateral movement in the BB is noticeably less than the Lynskey-built titanium and Planet X carbon fiber frames I have been riding lately. I don't think this really makes a difference in real life, but the difference is there. As far as front end stiffness is concerned, I guess it is good because I haven't noticed anything out of the ordinary there. The bike tracks and corners well, and holds its line confidently in the corners. The frame is also reasonably comfortable when I am using my Ambrosio Nemesis / Bontrager tubular combo, or using my Campy Zonda 2-Way Fit / Hutchinson tubeless combo. With the Mavic Cosmic Carbone SL / Veloflex Corsa clincher combo, the ride can be buzzy / harsh at times, especially over chip seal.
Wheels / Components: I have been riding the Ambrosio Nemesis / Bontrager Race X-Lite tubular (290 tpi, latex tube) combo a lot lately. The stiffness of the wheels seems good (no brake rub front or rear), and the tires ride pretty well at 120 psi (I am a big guy, so I pump them up a bit higher than usual). Although I should note that it is not quite the difference that I remember feeling between clinchers and tubulars when I first made the switch about seven years ago. This is probably a testament to how far clinchers have come along in the past few years. I also really enjoy the ride with the Campy Zonda 2-Way Fit / Hutchinson tubeless combo on this frame; it compliments the frame well IMO and it is definitely the most comfortable setup among all my options.
I also want to share my thoughts on SRAM Red. I just rented a bike with Campy Record on it, and after riding it for a day I couldn't wait to go back to SRAM. IMO, double-tap shifting is hard to beat (my big hands did not get along well with the thumb shifters), the ergonomics are really good, and of course the weight is hard to beat. Having ridden Di2, I wouldn't change SRAM for anything else at this point other than Ultegra Di2.
This is all I can think of for now...