Yeah, youll need the cold stuff. At least for mornings/ evenings. Being from Canada it may not be too bad for you. Should feel like home that time of year. Some springs it warms up a little faster, but people are still skiing around that time of year. With a windchill it can be pretty vicious up there. Mount Mitchell has a -70F? record with the windchill, but thats at the coldest place. SC isn't as bad for the cold stuff. Especially between TN, VA, and NC at the higher elevations- its like a triangle from the TN/NC state line you can expect some chilliness. Dont know about the cold with these warmer drier years now, it may not be as bad except for a late cold snap. Its the only area in the South where things wont shut down for winter weather either. Anywhere from Greenville to Tennessee, and Georgia to Virginia through the Appalachians is pretty nice to ride. Smokey Mountain Nat'l Park, Blue Ridge Parkway, Hiawassee, little switzerland, linville falls, Murphy- has a high elevation plateau around it, unicoi range, etc. and most back highways are really nice rides. Greenville, Asheville, Boone, etc. are all pretty nice towns, but you'll get a lot of Atlanta transplants. Murphy, Franklin, Canton, Waynesboro you'll want to be a little cautious of "hillbillie" drivers. I was with a group of 30 who had to "pump up a fool's head" when he had a problem with sharing the road. Cost us all an air pump. Although, that was 10 years ago. Most of these people have been replaced by yuppies, but they are just as dangerous- in nicer cars.
Be careful in smaller groups. Be very careful solo or pairs. Plus, there are a lot of places where you cant be seen behind hillcrests there almost a whole day trip long. Continuous blind spots.
Let us know if you meet "bubba". There are still a few up there. I still have family that 'shines up yonder.