THM, lighter and stiffer with out board.
The new stronglight and time, though they have the integrated spindle, the bearings will still remain inside of the shell.
Though changing to a non-outboard style bb, will not effect the chainline enough to hurt shifting or have any negative impact(it will usually improve it). It will also reduce the Q-factor, which is a good thing for most riders.
So when do you think you'll see one of these lighter, stiffer Claviculas--in a 175mm compact flavor, thank you--in Ralph's Shack?