Have been a long time Arione user, it was ok but I still would succumb to discomfort in the perennial area/hot spots. I went from a normal cx carbon rail to the cx with carbon base/rails. I started getting saddle sores which i found was due to the carbon base just not flexing enough. So although I settled with an arione, I thought there had to be something better.
First thing was trying to alleviate the perennial discomfort. So I tried some cutout saddles, first I tried the Romin evo pro, which was a nice saddle, put pressure on the sit bones and relieved the perennial area. But the kick at the back was uncomfortable and pushed in to much when I was in an upright position. It also prevented me from shifting my weight back.
I then tried the toupe, much better for me, gave me the flexibility to adjust my position, nice in the drops but it was a bit hard on the sit bones, felt like all my weight was on 2 points a bit.
The saddle I currently use now is a 2012 Ritchey biomax WCS saddle. It's a traditional SLR style shape saddle with a cutout, a slight dip in the middle and for me this saddle just disappears underneath, first time that's happened to me. It seems like the density of the padding, cutout, shell flex is in the exact proportions my arse needs. Highly recommend it, the saddles weighs 205g, not the lightest out there but decent enough for a TI rail saddle, leather covered like the SLR and reasonably priced.
I have a nago evo coming in the mail, not sure if I'll bother trying that out since I've been so happy with the biomax. Also I've gone off carbon rails, I believe they're just too rigid for a rail, when a rail should be acting more like a leaf spring, I think TI rails are just better suited for the task.
Time to ebay some saddles.