@Corky: On my rain bike (A Trek Emonda SL) which came fully decked out resplendent in Shimano 105, the first thing I did was to strip off everything and replace it with Campy SR. Except for the brakes. The Shimano brakes simply had more clearance and I wanted to run 25mm tires with full fenderd. It worked. I was wondering how the brakes would feel using the Campy levers and quite honestly they feel just fine. The 105 calipers are not as beefy and stiff as the higher end calipers but they were fine for this purpose. On a new build I am using Shimano 9100 brakes with Campy levers. The clearance is good and it is also consistent regardless of rim width. With Campy skeleton brakes, as the width of the rim increases and you have to adjust the calipers to accommodate this, a side effect is that the arms of the skeleton brakes come down lower and can actually hit the top of the tire. You can check this out simply by watching what happens when you completely remove the brake cable and see how the arms want to come downwards on top. In contrast, the new Shimano brakes do not change at all this way. Regardless of how wide you adjust them, the clearance remains the same and you can get up to about a 28mm tire underneath the new 9100 brakes, depending on the width of the rim you use of course.
The spring retention method fo Campagnolo brake pads is a little annoying, but those springs are easily removeable as I've done on mine. And as @SuperDomestique pointed out in my C60 build thread, the pads are pretty easily removed simply be prying them out a bit to get started then taking some pliers and pulling them out. Either way, not really an issue.
I actually like the quick release of the Campagnolo brakes, being at the lever. But if you do go with the Shimano brakes, then you have double the release action. For this reason, it would be much more problematic using Shimano levers with Campy brake calipers since in that case you would have no release at all.
Lever reach: Campy supplies a couple of spacers to adjust lever reach for larger hands. I've never felt the need to use them, but they are there.
Skeleton brakes are so unaero.
Ok... I've never noticed them slowing me down too much, until I want them to of course.