My existing bike is a Canyon CF SLX 2014 XL, but I am already on my 4th frame, and just about to put a warranty claim in for this one (all the same failure point).
Definitely a Colnago C60 would be much sturdier. There is a reason it weights 1200gr...
1205 gm in Art Decor 50S, with Headset installed, seatpost clamp and cups for Ultra Torque cups. If u compare like others do, and show the weight without headset (i guess at least 65-70 gm), Ultra Torque Cups (30 gm?), and seatpost clamp, the weight will be less then 1100 gm. If u show the weigh as Pinarello do (without paint), seem that C60 is lightweight frame, and without compromise in term of realibility or riding caracteristics just to save some non important weight
And about the tire clearance. I have 2016 year model, and i was riding whole season, including winter time where there was a wet roads with small stones etc..
When i bought the frame i was riding Attack/Force tires (22/24), then switched to Vittoria Corsa G+ 25mm (which look much wider), then to Conti 4Season 25mm for winter time. When i was cleaning the frame, noticed the scratches under the rear stay (probably tire picked up some stones and produce this scratches). Nothing too serious, just cosmetic.
But if i buy again C60, i'll just put trasnaparent Lizard Skin on this part (i have now, after i realize that scratches), or probably i'll be carefull with Vittoria Corsa G+ tires in 25 mm, which are much wider (and heavier), compared to Conti 4Season or Vittorica Corsa G+ 25 mm in tubular version.