The key part of comfort is a saddle what match your rear
eg When you have wide sitbones a (too) small saddle never will be comfortable.
From road.cc today, talking about Fizik's approach to saddles;
The Italian company undertook a three year study in collaboration with Professor Rodger Kram of the University of Colorado integrative Physiology Department Locomotion Lab and they found that the width of your sit bones make no real difference to the width of the saddle you should be riding (they do if you ride a more upright bike). Instead what their research found was that the determining factors in whether a wider or narrower saddle would work better for a a performance cyclist was a combination of weight and power output/speed.
It is true that the higher your power output the more weight will be born by your feet, so if you were trying to keep PSI static then you could reduce saddle surface area and come out the same. The thing is though, if you look at a pressure heatmap, pressure isn't evenly distributed all over the saddle, it is concentrated on skeletal structures, so it couldn't be a 1 - 1 ratio of reducing pressure and surface area. If we were to accept that it was all about PSI though, then that would mean that a heavier rider of the same power output should run a wider saddle than their skinny counterpart.
I am inclined to think that power output can certainly play a role in how comfortable a wide/narrow saddle is, but it certainly isn't the sole determinant.
They may be right that sit bone width doesn't correlate to saddle preference, except on a more upright bike, but that is because performance riders rotate their pelvises forward to a degree that the sit bones are no longer actually the primary load bearing skeletal structures. The pubic ramus is actually the bone structure that most of us sit on, and it is a heck of a lot more difficult to measure accurately. So in my opinion, Fizik is right, but for the wrong reasons. It is not that skeletal structure width is unimportant, it is just that saddle makers/bike shops are using measuring the wrong structure (and sit bone width is not a good proxy of pubic ramus width as the ratio is not fixed).