With the Colnago, you get Colnago handling - perhaps a little slow feeling at slow speed, very stable and predictable at high speed and handles bumps well. Ride any Colnago (I've owned 13 so far - dumb I know but what's an old retired guy to do but ride his bike and buy more in winter when it's too crummy outside to ride?) and they all handle about the same for the same size. Ride quality may differ with my Master and C40s somewhat smoother than my EPS or Extreme Power. Personally, I love C40s and keep buying them any time I see one my size on eBay or elsewhere so I'll have enough to last me til I quit riding.

As for stiffness and compliancy, I haven't ridden a C59. However, I'd rate both my Parlees a little less stiff and more compliant than my EPS, my most recent Colnago. Then again, tell Parlee what you want and they'll build it.

Any difference in handling