The next crusade for WADA--Exercise in a pill.

[mdeth1313]

They already went there in the article:
"Exercise in a Pill"

http://www.comcast.net/articles/news-sc ... cise.Pill/

[DocRay]

Most drugs (>90%) that have effects in mice don't work in humans.
Resveratrol is found in red wine.

[gumgardner]

Most drugs (>90%) that have effects in mice don't work in humans.
Resveratrol is found in red wine.

I love red wine, buit it gives me an instant headache (I get cluster headaches). Is there a wine that lacks the ingrediant that causes these headaches? I know they isolated the chemical/ingrediant. Just wondering.

[_SJ_]

Yeah, the ingredient is called "alcohol" - take it out of red wine and it's no more headache.

[gumgardner]

No that's not it. I can drink all types of alcohol except red wine. There is a certain ingrediant.

Ok did some research.. Red wines are made with the skins intact. White wines have the skin removed. The ingrediant is in the skin they believe. I may need to pull out my highschool chemistry kit.

[DocRay]

No that's not it. I can drink all types of alcohol except red wine. There is a certain ingrediant.

It's likely the sulfites they use in most wines as a preservative. Try sulfite-free wines (sometimes sold as organic wines).

[swinter]

I think the resveratol is in the skins, which is why it's found in red wine and not white.

You can buy it in capsule form at GNC or on the web for less. No headache. (No buzz either, though.)

I get mine here:

http://www.wholehealth.com/index.cfm?fu ... uct_ID=214

P.S. -- This blurb on the website cracked me up. Maybe next year, a lab mouse in yellow:

Researchers from the Institute of Genetics and Molecular and Cellular Biology in Illkirch, France reported that the red wine compound, resveratrol, doubled the athletic endurance of lab mice,

[Powerful Pete]

It's likely the sulfites they use in most wines as a preservative. Try sulfite-free wines (sometimes sold as organic wines).

Although white wines usually have more than their fair share of sulfites... (more than reds, usually, IIRC).

[Mr.Gib]

No that's not it. I can drink all types of alcohol except red wine. There is a certain ingrediant.

Ok did some research.. Red wines are made with the skins intact. White wines have the skin removed. The ingrediant is in the skin they believe. I may need to pull out my highschool chemistry kit.

The answer to your question is histamines. They are present in greater quantities in red wine then in white. Some whites can get you also so be careful. If you take an antihistamine before you drink red wine the problem may be solved (but you might also fall asleep).

The colour in red wine comes from contact with the skins. Almost all red grapes have white flesh inside. Whites can also be made with skin contact depending on the style desired.

I know a little bit about cycling but a whole lot about wine.

[TheFatGuy]

I was under the impression it is the tanic acid that causes headaches-

I GET THEM TOO.

[Mr.Gib]

I was under the impression it is the tanic acid that causes headaches-

I GET THEM TOO.

Tannic acid is a component of the skins that adds that astringent mouth feel to red wines. I am not sure of the chemical connection between the histamines and the tannic acid other then that they both reside in the finished product. You will get just as much tannic acid eating grapes (skins) or the skin of other fruits and to my knowledge this does not cause the headaches discussed here.

[HTFU]

Resveratrol is just an example, but it wasnt the subject of the study. Dont rush out and buy boxes of wine by the crate. It will be gibberish to most people, but here is the abstract from the journal article:

The benefits of endurance exercise on general health make it desirable to identify orally active agents that would mimic or potentiate the effects of exercise to treat metabolic diseases. Although certain natural compounds, such as reseveratrol, have endurance-enhancing activities, their exact metabolic targets remain elusive. We therefore tested the effect of pathway-specific drugs on endurance capacities of mice in a treadmill running test. We found that PPARβ/δ agonist and exercise training synergistically increase oxidative myofibers and running endurance in adult mice. Because training activates AMPK and PGC1α, we then tested whether the orally active AMPK agonist AICAR might be sufficient to overcome the exercise requirement. Unexpectedly, even in sedentary mice, 4 weeks of AICAR treatment alone induced metabolic genes and enhanced running endurance by 44%. These results demonstrate that AMPK-PPARδ pathway can be targeted by orally active drugs to enhance training adaptation or even to increase endurance without exercise.