I'm beginning to wonder if Froome was setup. It makes no sense to take dozens of puffs of an inhaler. It's not going to help more or make you faster. You can't imagine that he'd take the more potent pill form once during a race.
Or, the BB had the drug in it and it was a doping mistake.
There are anabolic properties if an extreme amount is taken like, let's say, over 100% of the UCI limit. Go ahead and google "salbutamol anabolic". There's also the possibility that it was used as a masking agent for something else as well. Not sure about what delivery system they actually chose but in any case, over 200%
isn't a "woops, one too many puffs ha-ha-ha" mistake.
According to this book it only has an anabolic effect if its taken orally: Medical Toxicology of Drug Abuse: Synthesized Chemicals and Psychoactive Plants
By Donald G. Barceloux.
Like I said, if you google "salbutamol anabolic" there are plenty of papers that describe the PED aspect in detail. Yes there are others that also claim the other way but that's science--the consensus is the accepted fact, not outliers. The only a PED "if taken orally" argument is a stretch of truth -- oral administration only means that the same dosage is more potent, as nowhere near as much gets into the blood stream if inhaled. According to a paper hosted on WADA's own website, it's actually extremely difficult
for urine to contain a high concentration if it was administered through an inhaler, as basically only as much that was directly swallowed is found:
Previous studies have demonstrated that after oral administration, the majority of salbutamol is found in the urine either as the parent compound (24-33%) or as conjugated sulfate metabolite (48%).On the contrary, no significant biotransformation occurs in the lungs, thus the percentage of salbutamol metabolite depends mainly on the percentage of the dose that is swallowed and absorbed from the gastrointestinal tract.
The urinary results confirmed that after inhalation the enantiomeric ratio between S(+) and R(-) of the non metabolized and of the metabolized salbutamol strongly depends on the percentage of the dose that is swallowed.
https://www.wada-ama.org/sites/default/ ... report.pdf
This means that either:
a) He knowingly inhaled an egregious amount well over the limit and happened to accidentally swallow most of it
rather than exhale (we're talking several
more canisters than allowed, not an extra puff or two)
b) Froome & Co. is lying and he definitely took it orally