Sure
Pretty much the whole Cervelo Bigla Team use the 2-positions seatpost.
My Cervelo S3
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kgt wrote:IMO a 48 cm frame would fit you better.
Not really. A smaller frame would require even more spacers. And Cervelo uses the same seat tube angle across all frame sizes, so a smaller frame wouldn't address the saddle position issue either. Needs a two-position seatpost from an S5, and run it in the zero-offset configuration. Here is Dan Martin's old bike doing the same: